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Combigan Eye Drops

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Combigan Eye Drops

BRIMONIDINE + TIMOLOL - Combigan Eye Drops

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Starting from $18.80

Combigan enjoys huge popularity for the effective treatment it provides to manage of open-angle glaucoma. Buy Combigan Eye Drops from our online drug cart at best rates.

Quantity Strength Price Unit Price
1 Bottle Combigan Solution 0.2-0.5 5ml Bottle $19.19 $19.19
3 Bottle Combigan Solution 0.2-0.5 5ml Bottle $56.39 $18.80

A succinct summary of Combigan:

Combigan is a combination therapy that employs two effective drugs for the treatment of Glaucoma and ocular hypertension (high pressure inside the eye). High pressure inside the eye is the leading cause of blindness in many, and the reduction of this pressure is of extreme importance to prevent blindness. This product encloses Brimonidine and Timolol. These medications are used together to attain synergistic effects i.e. double the effect.

Mode of action of Combigan:

Timolol is the first β blocker approved to be used opthalmically for the treatment of open-angle glaucoma. It works by reducing the formation of aqueous humor by ciliary body in the eye. It reduces the intraocular pressure by 18–34% below baseline within few days of treatments.

Brimonidine is a α2 agonist, that inhibits the action of adenylate cyclase which in turn reduces the cAMP concentration and therefore the aqueous humor production by the ciliary body.

Posology of Combigan:

Apply one drop of Combigan in the affected eye two times a day, maintaining a gap of  12 hours. Incline you head backward and pull the eyelids to create a pouch. Instill a drop of this medicine to the affected eyes and close your eyes for 2 or 3 minutes, do not blink or squint in this period. Wait for at least 10 minutes before applying any other eye drop.

Contraindications of Combigan:

Certain contradictory cases of Combigan are

  • Congestive heart failure, Coronary artery disease
  • Low or high blood pressure, Circulation problems
  • Depression
  • Diabetes
  • Thyroid disorder
  • Allergy towards any component of the eye drop
  • Myasthenia gravis



Drug interaction of Combigan:

Certain drug interactions of Combigan are

  • Digoxin, Digitalis
  • Isocarboxazid, Linezolid, Phenelzine,
  • Carvedilol, Labetalol, Metoprolol
  • Reserpine
  • Amitriptyline, Bupropion, Clomipramine


Side effects:

Certain side effects associated with the use of Combigan eye drop such as drowsiness, tired feeling, mild itching, redness, or irritation of your eyes, mild stinging or burning when using the eye drops.


  • Reinsert your lenses after a gap of 15 minutes, after the application of the drug, if you are using any.
  • Whether Combigan will harm an unborn harm an unborn baby is not known. Do not take this drug without medical advice if you are pregnant. 
  • Combigan should not be given to a child without medical advice.

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